TRIM22 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comTRIM22 Polyclonal Antibody for Human(Homo sapiens)

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TRIM22 (Gene name),

E3 ubiquitin-protein ligase TRIM22 (Protein name ), TRI22_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TRIM22(RNF94;STAF50);

Protein name:

E3 ubiquitin-protein ligase TRIM22;

Alternative:

RING finger protein 94;50 kDa-stimulated trans-acting factor;Tripartite motif-containing protein 22;Staf-50;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with HIV-1 Gag polyprotein; this interaction seems to reduce gag production or virus budding. Interacts with EMCV protease 3C; this interaction leads to viral protease ubiquitination.

Function:

Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.

Subcellular Location:

Cytoplasm Nucleus Nucleus speckle Nucleus Cajal body Localizes predominanltly into the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.

Protein Attributes:

Sequence length:

498

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

498:

AGIVSFFNVT | NHGALIYKFS | GCRFSRPAYP | YFNPWNCLVP | MTVCPPSS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:10346

String:

Q8IYM9

Pfam:

PF00622

MIM:

606559

STRING:

9606.ENSP00000369299

UniGene:

Hs.501778

SMR:

Q8IYM9

Uniprot:

Q8IYM9

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ELISA Kit for Human E3 ubiquitin-protein ligase TRIM22

Cat.:

E5012h

Price:

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Human E3 ubiquitin-protein ligase TRIM22

Cat.:

U5012h

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Manual:

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Packing:

96T

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Polyclonal Antibody for Human E3 ubiquitin-protein ligase TRIM22

Cat.:

P5012Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human E3 ubiquitin-protein ligase TRIM22

Protein for Human E3 ubiquitin-protein ligase TRIM22

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning of a new interferon-induced factor that represses human immunodeficiency virus type 1 long terminal repeat expression."
Tissot C. , Mechti N.
J. Biol. Chem.270:14891-14898(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INDUCTION;TISSUE SPECIFICITY;VARIANT THR-242
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ASN-155
tissue: Lung.
tissue: Testis.
3.

"The tripartite motif family identifies cell compartments."
Reymond A. , Meroni G. , Fantozzi A. , Merla G. , Cairo S. , Luzi L. , Riganelli D. , Zanaria E. , Messali S. , Cainarca S. , Guffanti A. , Minucci S. , Pelicci P.G. , Ballabio A.
EMBO J.20:2140-2151(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
4.

"Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells."
Obad S. , Brunnstrom H. , Vallon-Christersson J. , Borg A. , Drott K. , Gullberg U.
Oncogene23:4050-4059(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
5.

"Identification of TRIM22 as a RING finger E3 ubiquitin ligase."
Duan Z. , Gao B. , Xu W. , Xiong S.
Biochem. Biophys. Res. Commun.374:502-506(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;AUTOUBIQUITINATION;MUTAGENESIS OF CYS-15
6.

"The interferon response inhibits HIV particle production by induction of TRIM22."
Barr S.D. , Smiley J.R. , Bushman F.D.
PLoS Pathog.4:E1000007-E1000007(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;INTERACTION WITH HIV-1 GAG POLYPROTEIN;MUTAGENESIS OF CYS-15 AND CYS-18
7.

"Dynamic localization of tripartite motif-containing 22 in nuclear and nucleolar bodies."
Sivaramakrishnan G. , Sun Y. , Tan S.K. , Lin V.C.
Exp. Cell Res.315:1521-1532(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INDUCTION
8.

"B30.2/SPRY domain in tripartite motif-containing 22 is essential for the formation of distinct nuclear bodies."
Sivaramakrishnan G. , Sun Y. , Rajmohan R. , Lin V.C.
FEBS Lett.583:2093-2099(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF CYS-15; CYS-18 AND 493-VAL-CYS-494
9.

"Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain."
Gao B. , Duan Z. , Xu W. , Xiong S.
Hepatology50:424-433(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus."
Eldin P. , Papon L. , Oteiza A. , Brocchi E. , Lawson T.G. , Mechti N.
J. Gen. Virol.90:536-545(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EMCV PROTEASE 3C
11.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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